![]() ![]() Lyosecretome-loaded SB scaffolds (SBlyo) were prepared using an absorption method. SB scaffolds were loaded with lyosecretome, a freeze-dried formulation of mesenchymal stem cell (MSC)-secretome, containing proteins and extracellular vesicles (EVs). ![]() In the present study, a new strategy to improve SB osteoinductivity was developed. SmartBone ® (SB) is a biohybrid bone substitute advantageously proposed as a class III medical device for bone regeneration in reconstructive surgeries (oral, maxillofacial, orthopedic, and oncology).
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